Polynucleotides in London: The Regenerative Treatment for Skin and Hair

Polynucleotides are a regenerative injectable treatment that supports the skin to repair and renew itself. Often derived from purified fragments of salmon DNA, they work with your own biology, prompting the cells responsible for firmness and repair rather than adding volume. Available in London and increasingly well known, they are used for skin quality, the delicate under-eye area, and the scalp, with results that build gradually.

What are polynucleotides?

Polynucleotides are chains of purified DNA fragments, most commonly sourced from salmon, that are highly compatible with human tissue. Once injected, they act as a scaffold and a signal, supporting the skin’s natural repair processes. They sit within a growing area often called regenerative aesthetics, which focuses on improving the health and quality of tissue rather than simply changing its shape.

This is a treatment about condition rather than contour. It does not fill or reshape. It aims to leave the skin healthier, better hydrated, and more resilient over time.

The salmon origin sometimes surprises people, so it is worth explaining. The DNA fragments are purified to a high, medical-grade standard, and the material is used because it is highly compatible with human tissue and well tolerated. It is not the fish itself, but a refined ingredient prepared for clinical use. If you have a fish allergy, tell your clinician, as this will be part of the suitability discussion.

How do polynucleotides work?

Once in the skin, polynucleotides stimulate fibroblasts, the cells that produce collagen and elastin, and support hydration and repair. Over the weeks that follow, this can improve skin quality, texture, and firmness. The change is gradual, because it relies on your own skin responding rather than on an immediate physical effect.

It helps to distinguish three related ideas. Filler adds volume. Bio-remodelling, such as Profhilo, hydrates and stimulates across an area. Polynucleotides are regenerative, supporting repair at a cellular level. They overlap in that all improve the skin, but they are not the same, and our full skin boosters comparison sets out where each fits.

Polynucleotides for the under-eyes

The under-eye area is one of the most popular uses, because the skin there is thin and delicate and responds well to a treatment focused on quality rather than volume. Polynucleotides can improve texture and the condition of thin under-eye skin over a course of sessions. They are not a fix for every under-eye concern, though. Where the issue is a true hollow or pigment, other approaches may suit better, which is why an honest assessment of your under-eye concern matters first.

Polynucleotides for hair loss

Polynucleotides are also used on the scalp to support the hair environment, and interest in this area is growing. The evidence is still developing, so it is important to be measured. This is not a guaranteed route to regrowth, and it is not right for every type of hair loss. For some people it may form part of a wider plan, and a proper assessment of the cause of your hair thinning always comes first.

Polynucleotides vs Profhilo and other skin boosters

Many people benefit from a combination over time. The point of a comparison like this is not to crown a winner, but to match the treatment to your concern.

What to expect: sessions, timeline and results

Polynucleotides are typically given as a course of sessions spaced a few weeks apart, as the regenerative effect builds with repetition. Many people notice improvement in skin quality gradually over the weeks following each session, with maintenance treatments later to sustain it. Your clinician will advise on the number of sessions, as it depends on the area and your skin. Results vary between individuals, so timelines are a guide rather than a promise.

Polynucleotides are often used alongside other treatments rather than instead of them. Because they focus on skin health, they can complement treatments that address volume or movement, supporting the quality of the skin while another treatment addresses structure. Any plan like this is decided at consultation, in an order and at a pace that suits your skin, rather than combining treatments for the sake of it.

Comfort, downtime and side effects

Most people tolerate the treatment well. Afterwards, minor swelling, redness, or small bruises at the injection points are possible and usually settle within a few days. As with any injectable, there are small risks, and any medical treatment carries some risk. These are discussed at your consultation, along with your suitability and simple aftercare.

Polynucleotides in London at The Beauty Script

Our approach is medically-led and consultation-first. You can see the detail of our polynucleotides treatment on its own page. Before recommending it, we assess your concern, your skin, and, for hair, the likely cause of thinning, and we are honest about what the treatment can and cannot do. Care is led by a registered nurse prescriber. The clinic is Save Face accredited and JCCP registered, and treatments are carried out in CQC-regulated premises. If you would like a clear, realistic opinion on whether polynucleotides suit you, a consultation is the right starting point.